Revista argentina de microbiología, 2014-07, Vol.46 (3), p.256-268
2014
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Details
- Autor(en) / Beteiligte
- Titel
- Microbicides for preventing sexually transmitted infections: Current status and strategies for preclinical evaluation of new candidates
- Ist Teil von
- Revista argentina de microbiología, 2014-07, Vol.46 (3), p.256-268
- Ort / Verlag
- Argentina
- Erscheinungsjahr
- 2014
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Microbicides are a new tool, still under investigation, which could help prevent infection by the human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs). Increasing evidence shows that the complexity of sexual transmission of viral pathogens requires the identification of compounds able to block the early events during the cycle of viral infection. In this manuscript we provide a comprehensive review of the different microbicide strategies that have been studied or are currently being considered for STI prevention, particularly emphasizing those having the potential to block HIV infection. The manuscript also reviews the complex process that is required to conduct future clinical studies in humans and concludes with a brief discussion of the strategies that could be part of the immediate future in microbicide research.
- Sprache
- Spanisch
- Identifikatoren
- ISSN: 0325-7541DOI: 10.1016/S0325-7541(14)70080-XTitel-ID: cdi_proquest_miscellaneous_1629972502
- Format
- –
- Schlagworte
- Administration, Intravaginal, Administration, Rectal, Animals, Anti-Infective Agents, Local - chemistry, Anti-Infective Agents, Local - classification, Anti-Infective Agents, Local - isolation & purification, Anti-Infective Agents, Local - pharmacology, Anti-Infective Agents, Local - toxicity, Clinical Trials as Topic, Disease Models, Animal, Drug Approval, Drug Evaluation, Preclinical - methods, Enzyme Inhibitors - pharmacology, Female, Herpes Genitalis - prevention & control, Herpes Genitalis - transmission, HIV Infections - prevention & control, HIV Infections - transmission, Humans, Male, Multicenter Studies as Topic, Papillomavirus Infections - prevention & control, Papillomavirus Infections - transmission, Sexually Transmitted Diseases, Bacterial - prevention & control, Sexually Transmitted Diseases, Viral - prevention & control, Surface-Active Agents - pharmacology, Technology, Pharmaceutical - methods, Viral Proteins - antagonists & inhibitors, Virus Internalization - drug effects