Cancer letters, 2014-12, Vol.355 (2), p.201-209
2014
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Details
- Autor(en) / Beteiligte
- Titel
- Yes-associated protein 1 (YAP1) promotes human gallbladder tumor growth via activation of the AXL/MAPK pathway
- Ist Teil von
- Cancer letters, 2014-12, Vol.355 (2), p.201-209
- Ort / Verlag
- Ireland: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Nuclear overexpression of YAP1 was linked to poor prognosis with GBC. • This study examined the mechanistic roles of YAP1 in GBC. • YAP1 promotes GBC cell growth via activation of the AXL/MAPK pathway. • This work provided a rationale for YAP1 as a therapeutic target for GBC.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0304-3835eISSN: 1872-7980DOI: 10.1016/j.canlet.2014.08.036Titel-ID: cdi_proquest_miscellaneous_1629966573
- Format
- –
- Schlagworte
- Adaptor Proteins, Signal Transducing - biosynthesis, Adaptor Proteins, Signal Transducing - genetics, Adaptor Proteins, Signal Transducing - metabolism, Animals, Apoptosis - physiology, Cell cycle arrest, Cell growth, Cell Line, Tumor, Cell Nucleus - metabolism, Cell proliferation, Cell Proliferation - physiology, Enzyme Activation, Gallbladder cancer, Gallbladder Neoplasms - genetics, Gallbladder Neoplasms - metabolism, Gallbladder Neoplasms - pathology, Gene Expression Regulation, Neoplastic, Hematology, Oncology and Palliative Medicine, Heterografts, Humans, Kinases, MAP Kinase Signaling System, Mice, Mice, Nude, Mitogen-Activated Protein Kinases - genetics, Mitogen-Activated Protein Kinases - metabolism, Mortality, Oncogenes, Phosphoproteins - biosynthesis, Phosphoproteins - genetics, Phosphoproteins - metabolism, Proto-Oncogene Proteins - genetics, Proto-Oncogene Proteins - metabolism, Receptor Protein-Tyrosine Kinases - genetics, Receptor Protein-Tyrosine Kinases - metabolism, RNA interference, S Phase - physiology, Studies, Transcription Factors, YAP1