Details

Autor(en) / Beteiligte

• Lebenthal, Yael, MD
• Yackobovitch-Gavan, Michal, PhD
• Lazar, Liora, MD
• Shalitin, Shlomit, MD
• Tenenbaum, Ariel, MD
• Shamir, Raanan, MD
• Phillip, Moshe, MD

Titel

Effect of a Nutritional Supplement on Growth in Short and Lean Prepubertal Children: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study

Ist Teil von

• The Journal of pediatrics, 2014-12, Vol.165 (6), p.1190-1193.e1

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective To determine the effect of nutritional supplementation on height, weight, and body mass index (BMI) in short and lean prepubertal children. Study design A prospective, randomized, double-blinded, placebo-controlled trial of nutritional supplementation at the endocrinology department of a tertiary pediatric medical center of healthy, lean, short, prepubertal children 3-9-years-old. Anthropometry measurements were measured at 6 months. Results Two hundred participants (149 boys) entered the study and 171 (85.5%) completed the intervention period. Baseline characteristics including age, sex, height-SDS, weight-SDS, BMI-SDS, and dietary caloric and protein intakes were similar in the formula and placebo groups. ‘Good’ consumers (intake of ≥50% of the recommended dose) in the formula group significantly improved height-SDS ( P  < .001) and weight-SDS ( P  = .005) with no change in BMI-SDS compared with ‘poor’ consumers and the placebo group. In the formula-treated group a positive correlation was found between the amount of formula consumed per body weight and the gain in height-SDS (r = 0.44, P  < .001) and weight-SDS (r = 0.35, P  = .002); no significant correlations were found in the placebo group. No serious adverse events were reported during the study. Conclusions Nutritional intervention with the formula was found to be a feasible, effective, and safe approach for promoting the physical growth of short and lean prepubertal children.