Details

Autor(en) / Beteiligte

• Gabbai-Armelin, PR
• Cardoso, DAlves
• Zanotto, ED
• Peitl, O
• Leeuwenburgh, SCG
• Jansen, JA
• Renno, ACM
• van den Beucken, JJJP

Titel

Injectable composites based on biosilicate registered and alginate: handling and in vitrocharacterization

Ist Teil von

• RSC advances, 2014-09, Vol.4 (86), p.45778-45785

Erscheinungsjahr

2014

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The objective of the study was to prepare an injectable composite for bone regeneration based on the combination of a highly bioactive glass-ceramic (Biosilicate registered ) and alginate by optimizing the ratio of Biosilicate registered /alginate. These formulations were evaluated in terms of injectability, visco-elastic properties, degradation (i.e.mass loss, pH, calcium deposition) and cytotoxycity. The results showed that by mixing Biosilicate registered and alginate, it is possible to obtain an injectable biocomposite material that exhibits interesting elastic properties. Furthermore, the formulations with higher alginate (up to 20 wt%) content showed higher mechanical stability compared to pure Biosilicate registered . All formulations mineralized in Simulated Body Fluid (SBF) during the initial 4 days of testing. The cytotoxicity of conditioned media obtained viaincubation of the formulations showed negative effects on cell viability but this effect was nullified with increasing the number of washing post-treatments (especially in the case of the formulation containing Biosilicate registered /alginate of 42.5/7.5 wt%). Based on the results of the present study, it can be concluded that the material properties of injectable Biosilicate registered /alginate formulations seem suitable for bone regenerative applications, for which future studies should aim at biological evaluation in animal experimental models.