Details

Autor(en) / Beteiligte

• Jabs, Douglas A.
• Enger, Cheryl
• Dunn, J. P.
• Forman, Michael

Titel

Cytomegalovirus Retinitis and Viral Resistance: Ganciclovir Resistance

Ist Teil von

• The Journal of infectious diseases, 1998-03, Vol.177 (3), p.770-773

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

1998

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Cytomegalovirus (CMV) retinitis is among the most common opportunistic infections in patients with AIDS and a substantial cause of visual loss. With long-term therapy, resistant CMV may develop. In a prospective study of 108 patients with CMV retinitis, 80.6% of patients were found to have either a positive blood culture or positive urine culture for CMV at the diagnosis of retinitis. At diagnosis of retinitis, 0.9% and 2.7% of patients had a ganciclovir-resistant blood culture isolate and urine culture isolate, respectively. Of 76 patients initially treated with ganciclovir, 11.4% had a resistant blood or urine culture isolate by 6 months of treatment and 27.5% by 9 months. The development of ganciclovir resistance during follow-up correlated with the occurrence of CMV retinitis in the contralateral eye (odds ratio = 9.06, P = .003).