Details

Autor(en) / Beteiligte

• París, María M.
• Hickey, Sheila M.
• Trujillo, Mónica
• Ahmed, Amina
• Olsen, Kurt
• McCracken, George H.

Titel

The Effect of Interleukin-10 on Meningeal Inflammation in Experimental Bacterial Meningitis

Ist Teil von

• The Journal of infectious diseases, 1997-11, Vol.176 (5), p.1239-1246

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

1997

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Interleukin-10 (IL-10) is a cytokine with antiinflammatory effects. In a rabbit model of meningitis, IL-10 was given intracisternally or intravenously to evaluate the impact on inflammation induced by lipooligosaccharide (LOS), Haemophilus influenzae type b (Hib), or Listeria monocytogenes. Intracisternal IL-10 in concentrations >1 mg significantly reduced tumor necrosis factor-α (TNF-α) and lactate values in cerebrospinal fluid (CSF). Intravenous IL-10 (1 mg/kg) in two doses after intracisternal LOS significantly reduced CSF TNF-α and lactate. When Hib was used, animals were treated with ceftriaxone and dexamethasone with or without IL-10 (1 mg/kg). TNF-α was significantly reduced in animals treated with IL-10, dexamethasone, or both compared with levels in rabbits receiving ceftriaxone alone. Comparable results were obtained when L. monocytogenes was inoculated and animals were treated with ampicillin with or without IL-10, dexamethasone, or nothing. In conclusion, IL-10 modulates CSF TNF-α concentrations in experimental LOS, Hib, or L. monocytogenes meningitis. The maximal inhibitory effect was seen when IL-10 and dexamethasone were combined.