Details

Autor(en) / Beteiligte

• Linnartz-Gerlach, B
• Mathews, M
• Neumann, H

Titel

Sensing the neuronal glycocalyx by glial sialic acid binding immunoglobulin-like lectins

Ist Teil von

• Neuroscience, 2014-09, Vol.275, p.113-124

Ort / Verlag

United States

Erscheinungsjahr

2014

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Highlights • Siglecs bind to sialic acids of the intact glycocalyx. • Inhibitory Siglec-signaling keeps glial cells in a homeostatic status. • Microglial Siglecs are involved in modulation of neuron–microglia interaction. • Siglecs can be neuroprotective by preventing primary phagocytosis and the associated oxidative burst. • Siglec-3/CD33 variants are linked to Alzheimer’s disease.