Details

Autor(en) / Beteiligte

• Naorat, Sathapana
• Chittaganpitch, Malinee
• Thamthitiwat, Somsak
• Henchaichon, Sununta
• Sawatwong, Pongpun
• Srisaengchai, Prasong
• Lu, Ying
• Chuananon, Somchai
• Amornintapichet, Tussanee
• Chantra, Somrak
• Erdman, Dean D.
• Maloney, Susan A.
• Akarasewi, Passakorn
• Baggett, Henry C.

Titel

Hospitalizations for Acute Lower Respiratory Tract Infection Due to Respiratory Syncytial Virus in Thailand, 2008-2011

Ist Teil von

• The Journal of infectious diseases, 2013-12, Vol.208 (suppl 3), p.S238-S245

Ort / Verlag

United States: Oxford University Press

Erscheinungsjahr

2013

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• Background. Few population-based estimates of the incidence of respiratory syncytial virus (RSV) infection in low-or middle-income countries are available. We describe the incidence and epidemiology of hospitalizations for RSV-associated acute lower respiratory tract infection (ALRI) detected by active population-based surveillance in 2 rural Thailand provinces during 2008-2011. Methods. Patients hospitalized with ALRI were systematically sampled. Consenting patients provided nasopharyngeal swab specimens for RSV testing by real-time reverse-transcription polymerase chain reaction. Results. Of 13 982 enrolled patients hospitalized with ALRI, 1137 (8.1%) were RSV positive. After adjustment for sampling and nonenrollment, the incidence of RSV-associated ALRI hospitalization was 85 cases per 100 000 persons/year. The highest rates occurred among children aged <5 years (981 cases per 100 000 persons/year) and <1 year (1543 cases per 100 000 persons/year). Rates were low among older children and young adults but high among persons aged >65 years (130 cases per 100 000 persons/year). Eight (0.7%) RSV-infected study patients died during hospitalization. Annual RSV hospitalizations peaked during July-October with almost no documented RSV hospitalizations during January-June. Conclusions. Our findings demonstrate the substantial contribution of RSV to global ALRI burden, especially in children aged <5 years and the elderly, and underscore the urgent need for effective prevention measures.