Details

Autor(en) / Beteiligte

• Miller, Frederick W
• Leitman, Susan F
• Cronin, Mary E
• Hicks, Jeanne E
• Leff, Richard L
• Wesley, Robert
• Fraser, David D
• Dalakas, Marinos
• Plotz, Paul H

Titel

Controlled Trial of Plasma Exchange and Leukapheresis in Polymyositis and Dermatomyositis

Ist Teil von

• The New England journal of medicine, 1992-05, Vol.326 (21), p.1380-1384

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

1992

Quelle

MEDLINE

Beschreibungen/Notizen

• Polymyositis and dermatomyositis are the most common forms of a group of systemic inflammatory diseases affecting muscle, collectively known as the idiopathic inflammatory myopathies. Patients with these disorders are identified by the presence of proximal muscle weakness; elevations in serum levels of creatine kinase and other muscle-associated enzymes; characteristic electromyographic abnormalities; chronic mononuclear-cell infiltration, with evidence of the degeneration and regeneration of myocytes on muscle biopsy; and in patients with dermatomyositis, distinctive rashes on the hands and face. 1 They may also have cardiac, pulmonary, and gastrointestinal dysfunction that results in substantial morbidity and mortality. 2 , 3 The causes of these diseases are . . .