Details

Autor(en) / Beteiligte

• Shmueli, Einat
• Or, Reuven
• Shapira, Michael Y.
• Resnick, Igor B.
• Caplan, Orit
• Bdolah-Abram, Tali
• Wolf, Dana G.

Titel

High Rate of Cytomegalovirus Drug Resistance Among Patients Receiving Preemptive Antiviral Treatment After Haploidentical Stem Cell Transplantation

Ist Teil von

• The Journal of infectious diseases, 2014-02, Vol.209 (4), p.557-561

Ort / Verlag

Oxford: Oxford University Press

Erscheinungsjahr

2014

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• We examined the rate, clinical impact, and risk factors of cytomegalovirus (CMV) drug resistance in 561 patients who underwent 616 hematopoietic stem cell transplantations (HSCTs) over 5 years. Drug resistance was exclusively identified in haploidentical (haplo)-HSCT recipients receiving preemptive therapy, among whom the rate was 14.5%. Resistance appeared after prolonged treatment (median, 70 days), was associated with higher preceding viral load (P <. 001), and was the strongest predictor for disease by multivariate analysis. The high rate of drug resistance as interlinked with severe disease in haplo-HSCT recipients suggests the potential advantage of prophylactic over preemptive treatment in high-risk patients and highlights the need for better-tolerable anti-CMV drugs.