Details

Autor(en) / Beteiligte

• Lin, Li-Ling
• Huang, Hsuan-Cheng
• Juan, Hsueh-Fen

Titel

Deciphering molecular determinants of chemotherapy in gastrointestinal malignancy using systems biology approaches

Ist Teil von

• Drug discovery today, 2014-09, Vol.19 (9), p.1402-1409

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• •Systems biology aids anti-cancer drug development for gastrointestinal cancer.•Omics techniques can reveal potential signatures of chemotherapy responses at different molecular and cellular levels.•Systems biology approaches are used to identify targets for improving therapy strategies.•Network medicine provides systematically derived information for multidrug therapies. Gastrointestinal cancers are asymptomatic in early tumor development, leading to high mortality rates. Peri- or postoperative chemotherapy is a common strategy used to prolong the life expectancy of patients with these diseases. Understanding the molecular mechanisms by which anticancer drugs exert their effect is crucial to the development of anticancer therapies, especially when drug resistance occurs and an alternative drug is needed. By integrating high-throughput techniques and computational modeling to explore biological systems at different levels, from gene expressions to networks, systems biology approaches have been successfully applied in various fields of cancer research. In this review, we highlight chemotherapy studies that reveal potential signatures using microarray analysis, next-generation sequencing (NGS), proteomic and metabolomic approaches for the treatment of gastrointestinal cancers.