Details

Autor(en) / Beteiligte

• Gadea, Emilie
• Thivat, Emilie
• Merlin, Charles
• Paulon, Rodolphe
• Kwiatkowski, Fabrice
• Chadeyras, Jean-Baptiste
• Coudert, Bruno
• Boirie, Yves
• Morio, Béatrice
• Durando, Xavier

Titel

Brown Adipose Tissue Activity in Relation to Weight Gain During Chemotherapy in Breast Cancer Patients: A Pilot Study

Ist Teil von

• Nutrition and cancer, 2014, Vol.66 (7), p.1092-1096

Ort / Verlag

United States: Routledge

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Weight gain has been reported in early stage breast cancer patients during chemotherapy, but the involved mechanisms remain unclear. A chemotherapy-induced decrease of brown adipose tissue (BAT) activity may partly contribute to weight gain in these patients. A positron emission tomography/computed tomography scan was performed at baseline and after 1 course of docetaxel + trastuzumab treatment in 26 breast cancer women. Variation of the maximal standardized uptake value of BAT in the cervical and supraclavicular regions between the 2 measures was assessed according to weight changes. Overall, ¹⁸F-FDG uptakes in BAT decreased by 11.3% after 1 course of chemotherapy (p = 0.03). No correlation was found between the baseline values of ¹⁸F-FDG uptake and body mass index or age of patients, but as expected ¹⁸F-FDG uptake was dependent on season period. Among the patients, 35% gained weight, 25% lost weight, and 40% remained stable. Women who gained weight during chemotherapy experienced a significant decrease of ¹⁸F-FDG uptake in BAT (p = 0.005). Decreased activity of BAT was associated with body weight gain during chemotherapy. These original data suggest for the first time that BAT modulation by chemotherapy would be a potential contributor to body weight gain through blunted thermogenesis in breast cancer patients.