Cancer letters, 2014-12, Vol.355 (1), p.148-158
2014
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- Autor(en) / Beteiligte
- Titel
- MiR-124 represses vasculogenic mimicry and cell motility by targeting amotL1 in cervical cancer cells
- Ist Teil von
- Cancer letters, 2014-12, Vol.355 (1), p.148-158
- Ort / Verlag
- Ireland: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Abstract miRNAs have extensive functions in differentiation, metabolism, programmed cell death, and tumor metastasis by post-transcriptional regulation. Vasculogenic mimicry is an important pathway in tumor metastasis. Many factors can regulate vasculogenic mimicry, including miRNAs. In previous studies, miR-124 was found to repress proliferation and metastasis in different types of cancers, but whether it functions in cervical cancer remained unknown. Here, we demonstrate that miR-124 can repress vasculogenic mimicry, migration and invasion in HeLa and C33A cells in vitro . Furthermore, we reveal that the effect of miR-124 on vasculogenic mimicry, migration and invasion results from its interaction with AmotL1. MiR-124 regulates AmotL1 negatively by targeting its 3'untranslated region (3'UTR). We found that miR-124 can repress the EMT process. Together, these results improve our understanding of the function of miR-124 in tumor metastasis and will help to provide new potential target sites for cervical cancer treatment.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0304-3835eISSN: 1872-7980DOI: 10.1016/j.canlet.2014.09.005Titel-ID: cdi_proquest_miscellaneous_1611619529
- Format
- –
- Schlagworte
- 3' Untranslated Regions, AmotL1, Angiogenesis, Binding Sites, Breast cancer, Carcinoma - blood supply, Carcinoma - genetics, Carcinoma - metabolism, Carcinoma - secondary, Cell adhesion & migration, Cell growth, Cell Movement, Cervical cancer, Cervical cancer cells, Cloning, EMT, Epithelial-Mesenchymal Transition, Extracellular matrix, Female, Gene expression, Gene Expression Regulation, Neoplastic, HeLa Cells, Hematology, Oncology and Palliative Medicine, Humans, Membrane Proteins - genetics, Membrane Proteins - metabolism, Metastasis, MicroRNAs - genetics, MicroRNAs - metabolism, miR-124, Molecular Mimicry, Motility, Neoplasm Invasiveness, Neovascularization, Pathologic, Proteins, Signal Transduction, Transfection, Tumors, Uterine Cervical Neoplasms - blood supply, Uterine Cervical Neoplasms - genetics, Uterine Cervical Neoplasms - metabolism, Uterine Cervical Neoplasms - pathology, Vasculogenic mimicry