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MiR-124 represses vasculogenic mimicry and cell motility by targeting amotL1 in cervical cancer cells
Ist Teil von
Cancer letters, 2014-12, Vol.355 (1), p.148-158
Ort / Verlag
Ireland: Elsevier Ireland Ltd
Erscheinungsjahr
2014
Link zum Volltext
Quelle
ScienceDirect
Beschreibungen/Notizen
Abstract miRNAs have extensive functions in differentiation, metabolism, programmed cell death, and tumor metastasis by post-transcriptional regulation. Vasculogenic mimicry is an important pathway in tumor metastasis. Many factors can regulate vasculogenic mimicry, including miRNAs. In previous studies, miR-124 was found to repress proliferation and metastasis in different types of cancers, but whether it functions in cervical cancer remained unknown. Here, we demonstrate that miR-124 can repress vasculogenic mimicry, migration and invasion in HeLa and C33A cells in vitro . Furthermore, we reveal that the effect of miR-124 on vasculogenic mimicry, migration and invasion results from its interaction with AmotL1. MiR-124 regulates AmotL1 negatively by targeting its 3'untranslated region (3'UTR). We found that miR-124 can repress the EMT process. Together, these results improve our understanding of the function of miR-124 in tumor metastasis and will help to provide new potential target sites for cervical cancer treatment.