Medicinal research reviews, 2014-11, Vol.34 (6), p.1217-1241
2014
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Details
- Autor(en) / Beteiligte
- Titel
- Strategies in the Design of Small-Molecule Fluorescent Probes for Peptidases
- Ist Teil von
- Medicinal research reviews, 2014-11, Vol.34 (6), p.1217-1241
- Ort / Verlag
- United States: Blackwell Publishing Ltd
- Erscheinungsjahr
- 2014
- Quelle
- Wiley Online Library All Journals
- Beschreibungen/Notizen
- Peptidases, which can cleave specific peptide bonds in innumerable categories of substrates, usually present pivotal positions in protein activation, cell signaling and regulation as well as in the origination of amino acids for protein generation or application in other metabolic pathways. They are also involved in many pathological conditions, such as cancer, atherosclerosis, arthritis, and neurodegenerative disorders. This review article aims to conduct a wide‐ranging survey on the development of small‐molecule fluorescent probes for peptidases, as well as to realize the state of the art in the tailor‐made probes for diverse types of peptidases.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0198-6325eISSN: 1098-1128DOI: 10.1002/med.21316Titel-ID: cdi_proquest_miscellaneous_1611611892
- Format
- –
- Schlagworte
- design strategies, Drug Design, Fluorescent Dyes - chemistry, Humans, Molecular Probes - chemistry, Molecular Probes - pharmacology, peptidases, Peptide Hydrolases - drug effects, Peptide Hydrolases - metabolism, Protein Binding - drug effects, Signal Transduction, small-molecule fluorescent probes