Seizure (London, England), 2014-10, Vol.23 (9), p.732-739
2014
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Details
- Autor(en) / Beteiligte
- Titel
- Pharmacodynamic and pharmacokinetic interactions of perampanel and other antiepileptic drugs in a rat amygdala kindling model
- Ist Teil von
- Seizure (London, England), 2014-10, Vol.23 (9), p.732-739
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Antiepileptic drugs (AEDs) were administered in a rat amygdala kindling model. • At the doses tested, individual AEDs had no effect on seizure severity parameters. • Combination of perampanel with other AEDs reduced seizure severity parameters. • Perampanel plasma concentrations could be affected by the presence of other AEDs. • These findings support Phase III data and provide insight into AED interactions.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1059-1311eISSN: 1532-2688DOI: 10.1016/j.seizure.2014.06.001Titel-ID: cdi_proquest_miscellaneous_1609309378
- Format
- –
- Schlagworte
- Analysis of Variance, Animals, Anticonvulsants - blood, Anticonvulsants - pharmacokinetics, Anticonvulsants - therapeutic use, Antiepileptic drugs, Brain Waves - drug effects, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Interactions, EEG, Electroencephalography, Kindling, Kindling, Neurologic - drug effects, Localization-related epilepsy, Male, Motor Activity - drug effects, Neurology, Pyridones - blood, Pyridones - pharmacokinetics, Pyridones - therapeutic use, Rats, Rats, Wistar, Rotarod Performance Test