Details

Autor(en) / Beteiligte

• Kim, Hyoung-Chun
• Im, Doo-Hyun
• Jhoo, Wang-Kee
• Kim, Chin
• Wie, Myung-Bok

Titel

A LOW DOSE OF STREPTOZOTOCIN PREVENTS KAINIC ACID-INDUCED SEIZURES AND LETHAL EFFECTS IN THE RAT

Ist Teil von

• Clinical and experimental pharmacology & physiology, 1997-07, Vol.24 (7), p.503-505

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

1997

Quelle

Wiley Blackwell Single Titles

Beschreibungen/Notizen

• SUMMARY 1. The effect of streptozotocin (STZ), a nitric oxide (NO) donor, on kainic acid (KA)‐induced neurotoxicity was examined in Sprague‐Dawley rats. 2. The administration of KA (8mg/kg, i.p.) produced significant neurotoxicity accompanied with increased immuno‐reactivity for Fos‐related antigen in the rat hippocampus. 3. Pretreatment with STZ (15mg/kg, i.m.) significantly blocked the neurotoxicity induced by KA. 4. Thus, the neuroprotective effect of STZ may, at least in part, reflect the role of NO in inhibiting seizures.