Peptides (New York, N.Y. : 1980), 1991-03, Vol.12 (2), p.333-337
1991
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Details
- Autor(en) / Beteiligte
- Titel
- Calcitonin gene-related peptide, neurokinin A and substance P: Effects on Nociception and neurogenic inflammation in human skin and temporal muscle
- Ist Teil von
- Peptides (New York, N.Y. : 1980), 1991-03, Vol.12 (2), p.333-337
- Ort / Verlag
- New York, NY: Elsevier Inc
- Erscheinungsjahr
- 1991
- Quelle
- EZB-NALI5-00465 Elsevier Archive NL
- Beschreibungen/Notizen
- Calcitonin gene-related peptide (CGRP) was injected alone and in combination with substance P (SP) or neurokinin A (NKA) into the foream skin and temporal muscle of human volunteers. In the skin, 50 pmol of CGRP induced a wheal response and a delayed erythema. No pain was recorded. No interaction between CGRP and SP or NKA was observed. In the temporal muscle, 200 pmol of CGRP alone did not induce pain or tenderness but, in combination with SP or NKA, CGRP elicited a significant pain sensation. It is concluded that CGRP may be involved in neurogenic inflammation and that only SP, of the three peptides present in nociceptive C fibers, seems to be of major importance in relation to cutaneous nociception. Simultaneous neurogenic release of CGRP and other neuropeptides in skeletal muscle may induce myofascial pain.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0196-9781eISSN: 1873-5169DOI: 10.1016/0196-9781(91)90022-HTitel-ID: cdi_proquest_miscellaneous_16023202
- Format
- –
- Schlagworte
- Adult, Biological and medical sciences, Calcitonin gene-related peptide, Calcitonin Gene-Related Peptide - pharmacology, Calcitonin Gene-Related Peptide - physiology, Drug Interactions, Female, Flare, Fundamental and applied biological sciences. Psychology, Humans, Inflammation - etiology, Male, Muscles - drug effects, Muscles - physiology, Muscular tenderness, Neurogenic inflammation, Neurokinin A, Neurokinin A - pharmacology, Neurokinin A - physiology, Neuropeptides - pharmacology, Neuropeptides - physiology, Nociception, Nociceptors - drug effects, Nociceptors - physiology, Skin - drug effects, Skin Physiological Phenomena, Somesthesis and somesthetic pathways (proprioception, exteroception, nociception), interoception, electrolocation. Sensory receptors, Substance P, Substance P - pharmacology, Substance P - physiology, Vertebrates: nervous system and sense organs, Wheal