Details

Autor(en) / Beteiligte

• Karnik, N. A.
• Prankerd, R. J.
• Perrin, J. H.

Titel

Fluorometric and liquid chromatographic study of the binding of two coumarins to β-cyclodextrin

Ist Teil von

• Chirality (New York, N.Y.), 1991, Vol.3 (2), p.124-128

Ort / Verlag

New York: Alan R. Liss, Inc

Erscheinungsjahr

1991

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• The fluorescences of warfarin and phenprocoumon are enhanced following complexation with β‐cyclodextrin; (+)‐(R)‐ and (−)‐(S)‐phenprocoumons have different affinities for this cyclodextrin, whereas the corresponding enantiomers of warfarin have similar binding constants. Apparently, hemiketal formation in the case of warfarin minimizes chiral discrimination. This is confirmed using a β‐cyclodextrin bonded chromatography column on which the phenprocoumon enantiomers are separated, whereas those of warfarin are not.