Pharmacology, biochemistry and behavior, 1991-07, Vol.39 (3), p.569-574
1991
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- 3,4-methylenedioxyamphetamine (MDA) self-administration and neurotoxicity
- Ist Teil von
- Pharmacology, biochemistry and behavior, 1991-07, Vol.39 (3), p.569-574
- Ort / Verlag
- New York, NY: Elsevier Inc
- Erscheinungsjahr
- 1991
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- 3,4-Methylendioxyamphetamine (MDA), a drug with both stimulant- and hallucinogen-like properties, has been used for both medical and recreational purposes. The present study examined the reinforcing effects of MDA in rats and evaluated the resulting neurotoxicity. Self-administration of various doses (0.10, 0.05 and 0.025 mg/injection) was examined on a Fixed Ratio 1 (FR1) and a Progressive Ratio (PR) schedule. MDA supported self-administration at all doses on the FR1 schedule, but overdoses and deaths occured at the 0.10 mg/injection dose. The breakpoints established on the PR schedule were relatively low. High performance liquid chromatography analyses of the cortex, hippocampus, striatum and nucleus accmbens subsequent to MDA self-administration revealed significant depletion of 5-HT in the hippocampus. The results suggest that MDA is moderately reinforcing and that self-administration of low doses of MDA over several days is selectively neurotoxic.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0091-3057eISSN: 1873-5177DOI: 10.1016/0091-3057(91)90129-PTitel-ID: cdi_proquest_miscellaneous_16007098
- Format
- –
- Schlagworte
- 3,4-Methylenedioxyamphetamine - pharmacology, 3,4-Methylenedioxyamphetamine - toxicity, Animals, Biogenic Monoamines - metabolism, Biological and medical sciences, Brain Chemistry - drug effects, Chromatography, High Pressure Liquid, Cocaine - pharmacology, Corpus Striatum - drug effects, Corpus Striatum - metabolism, Dose-Response Relationship, Drug, Drug toxicity and drugs side effects treatment, Hippocampus - drug effects, Hippocampus - metabolism, Male, MDA, Medical sciences, Nervous System Diseases - chemically induced, Neurotoxicity, Nucleus Accumbens - drug effects, Nucleus Accumbens - metabolism, Pharmacology. Drug treatments, Prosencephalon - pathology, Rats, Rats, Inbred Strains, Reinforcement Schedule, Self Administration - psychology, Self-administration, Serotonin - physiology, Toxicity: nervous system and muscle