Details

Autor(en) / Beteiligte

• Hsu, W H
• Xiang, Hongding
• Rajan, A S
• Boyd, AE III

Titel

Activation of alpha sub(2)-adrenergic receptors decreases Ca super(2+) influx to inhibit insulin secretion in a hamster beta -cell line: An action mediated by a guanosine triphosphate-binding protein

Ist Teil von

• Endocrinology (Philadelphia), 1991-01, Vol.128 (2), p.958-964

Erscheinungsjahr

1991

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Activation of the sympathetic nervous system inhibits insulin secretion. We tested the hypothesis that activation of alpha sub(2)-adrenergic receptors on the beta -cell by epinephrine or clonidine attenuates insulin release by an effect on the voltage-dependent Ca super(2+) (VDCC) and examined the role of G-proteins in this signal transduction pathway. The data suggest that one mechanism by which alpha sub(2)-adrenergic agonists inhibit insulin secretion is by inhibiting Ca super(2+) influx through VDCC, an action that is mediated through a pertussis toxin-sensitive G-protein.