Anticancer research, 2014-10, Vol.34 (10), p.5313-5320
2014
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- Autor(en) / Beteiligte
- Titel
- The apelin-APJ system induces tumor arteriogenesis in hepatocellular carcinoma
- Ist Teil von
- Anticancer research, 2014-10, Vol.34 (10), p.5313-5320
- Ort / Verlag
- Greece
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The apelin-APJ system regulates angiogenesis, and is overexpressed in several types of cancer. The aim of this study was to clarify the role of the apelin-APJ system in the angiogenesis of hepatocellular carcinoma (HCC). Expressions of angiogenic factors and vascular markers were investigated in specimens from 90 HCC patients. A subcutaneous HCC tumor mouse model was treated with the APJ antagonist, F13A, and tumor growth and vascular development were assessed. APJ expression was observed in arteriole-smooth muscle. Higher amounts of APJ(+)-arteriole and apelin were detected in tumors (p<0.001 for both). APJ(+)-arteriole and apelin expression were more commonly observed in moderately- and poorly-differentiated than in well-differentiated HCC (p ≤ 0.003). HCC with irregular dilated arteries expressed higher levels of apelin (p=0.012). Tumor growth was inhibited by treatment with F13A (p<0.001), and arterioles were decreased in the treated group (p=0.047), in vivo. Apelin-APJ is overexpressed, and works as a signal for arteriogenesis in HCC.
- Sprache
- Englisch
- Identifikatoren
- eISSN: 1791-7530Titel-ID: cdi_proquest_miscellaneous_1586099457
- Format
- –
- Schlagworte
- Angiography, Animals, Apelin, Apelin Receptors, Carcinoma, Hepatocellular - diagnosis, Carcinoma, Hepatocellular - genetics, Carcinoma, Hepatocellular - metabolism, Carcinoma, Hepatocellular - pathology, Disease Models, Animal, Gene Expression, Humans, Immunohistochemistry, Intercellular Signaling Peptides and Proteins - genetics, Intercellular Signaling Peptides and Proteins - metabolism, Intercellular Signaling Peptides and Proteins - pharmacology, Liver Neoplasms - diagnosis, Liver Neoplasms - genetics, Liver Neoplasms - metabolism, Liver Neoplasms - pathology, Mice, Neovascularization, Pathologic - genetics, Neovascularization, Pathologic - metabolism, Receptors, G-Protein-Coupled - antagonists & inhibitors, Receptors, G-Protein-Coupled - genetics, Receptors, G-Protein-Coupled - metabolism, Tumor Burden - drug effects, Tumor Burden - genetics