Details

Autor(en) / Beteiligte

• Clemens, John D.
• Sack, David A.
• Chakraborty, J.
• Rao, M.R.
• Ahmed, Faruque
• Harris, Jeffrey R.
• van Loon, Frederik
• Khan, M.R.
• Yunis, Md
• Huda, S.
• Kay, Bradford A.
• Svennerholm, Ann-Mari
• Holmgren, Jan

Titel

Field trial of oral cholera vaccines in Bangladesh: evaluation of anti-bacterial and anti-toxic breast-milk immunity in response to ingestion of the vaccines

Ist Teil von

• Vaccine, 1990, Vol.8 (5), p.469-472

Ort / Verlag

Oxford: Elsevier Ltd

Erscheinungsjahr

1990

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• In a field trial conducted in Bangladesh, ingestion of either B subunit-killed whole cell (BS-WC) or killed whole cell (WC) oral cholera vaccines by mothers was associated with a 47% reduction of the risk of cholera in their non-vaccinated children aged under 36 months. Because vaccine-induced breast-milk immunity seemed a possible explanation for these findings, we evaluated anti-lipopolysaccharide (LPS) and anti-cholera toxin (CT) IgA antibody responses in breast milk collected during the trial from 53 lactating women who ingested three doses of BS-WC, WC, or an Escherichia coli K12 strain (K12). Despite induction of moderate vibriocidal (1.4 to 2.0-fold) and anti-CT (4.5-fold) serum antibody responses, the vaccines did not elicit significant rises of anti-LPS or anti-CT IgA breast-milk antibodies. The failure of the vaccines to elicit significant levels of breast-milk anti-cholera antibodies suggests an alternative explanation for protection of young children by maternal vaccination, such as interruption of maternal-child transmission of Vibrio cholerae 01.