Details

Autor(en) / Beteiligte

• Jouanguy, Emmanuelle
• Altare, Frédéric
• Lamhamedi, Salma
• Revy, Patrick
• Emile, Jean-François
• Newport, Melanie
• Levin, Michael
• Blanche, Stéphane
• Seboun, Eric
• Fischer, Alain
• Casanova, Jean-Laurent

Titel

Interferon-γ –Receptor Deficiency in an Infant with Fatal Bacille Calmette–Guérin Infection

Ist Teil von

• The New England journal of medicine, 1996-12, Vol.335 (26), p.1956-1962

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

1996

Quelle

MEDLINE

Beschreibungen/Notizen

• The attenuated strain of Mycobacterium bovis bacille Calmette–Guérin (BCG) is the most widely used vaccine in the world. In most children, inoculation of live BCG vaccine is harmless although it occasionally leads to a benign regional adenitis. 1 In rare cases, however, vaccination causes disseminated BCG infection, which may be lethal. Impaired immunity of the host is generally thought to be the pathogenic mechanism. Disseminated BCG infection has been reported in children with inherited immune disorders. Most of these children had severe combined immunodeficiency, which is characterized by an absence of T cells, and some had chronic granulomatous disease, which is . . .