Details

Autor(en) / Beteiligte

• Tanaka, H
• Shimizu, H
• Tatsuno, T
• Hirose, A
• Kumasaka, Y
• Nakamura, M

Titel

Autoradiographic evidence for the interaction of SM-3997 with 5-HT sub(1A) receptors in the rat brain

Ist Teil von

• Japanese journal of pharmacology, 1990-01, Vol.52 (3), p.504-508

Erscheinungsjahr

1990

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• ( super(3)H)8-OH-DPAT binding to rat brain sections and inhibition by SM-3997 were investigated. Very high densities of ( super(3)H)8-OH-DPAT binding sites were found in the dentate gyrus, entorhinal cortex, dorsal raphe, interpeduncular nucleus and lateral septum. In contrast, their densities were sparse in the substantia nigra, caudate putamen and choroid plexus. In the presence of SM-3997, ( super(3)H)8-OH-DPAT binding was strongly inhibited in all the brain structures we examined. The results indicate that SM-3997 binds to 5-HT sub(1A) receptors of rat brain sections.