Biochemical and biophysical research communications, 1990-10, Vol.172 (1), p.92-97
1990
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Protein oxidation and myelinolysis occur in brain following rapid correction of hyponatremia
- Ist Teil von
- Biochemical and biophysical research communications, 1990-10, Vol.172 (1), p.92-97
- Ort / Verlag
- San Diego, CA: Elsevier Inc
- Erscheinungsjahr
- 1990
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- Myelinolysis occurs following rapid correction of hyponatremia in both humans and experimental animals. Although the mechanism of this effect at present is unknown, we have examined the possibility that a rapid rise in serum sodium following hyponatremia potentiates an oxidative stress and results in the oxidation of cellular proteins. In these studies, rats treated with 1 M NaCl following 3 days of vasopressin-induced hyponatremia exhibited myelinolysis in the corpus striatum and thalamus as well as significant increases in soluble oxidized proteins in the brain. These changes did not occur in rats treated with 0.155 M (0.9%) NaCl following 3 days of hyponatremia.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0006-291XeISSN: 1090-2104DOI: 10.1016/S0006-291X(05)80177-9Titel-ID: cdi_proquest_miscellaneous_15749953
- Format
- –
- Schlagworte
- Analytical, structural and metabolic biochemistry, Animals, Arginine Vasopressin, Biological and medical sciences, brain, Brain - metabolism, Brain - pathology, Fundamental and applied biological sciences. Psychology, Hyponatremia - chemically induced, Hyponatremia - metabolism, Hyponatremia - pathology, Lipoproteins, myelin, Male, myelin, Myelin Sheath - ultrastructure, Nerve Tissue Proteins - metabolism, Organ Specificity, Oxidation-Reduction, Potassium - blood, Proteins, Rats, Rats, Inbred Strains, Reference Values, Sodium - blood, Sodium Chloride - pharmacology, Vasopressins