Details

Autor(en) / Beteiligte

• Gao, Fang

Titel

The Synthesis of the Amphiphilic Triblock Cationic Copolymer mPEG-PCL-PDMAEMA the Synthesis and its Impact Study on the Load and Transfected of siRNA

Ist Teil von

• Applied Mechanics and Materials, 2013-10, Vol.443 (Computer-Aided Design, Manufacturing, Modeling and Simulation III), p.605-608

Ort / Verlag

Zurich: Trans Tech Publications Ltd

Erscheinungsjahr

2013

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Polyphosphate is a biocompatible, modified and functionalized biodegradable polymer. It has a broad application prospects in the field of medical biomaterials. It is an excellent drug carrier material. In this essay, through the open-loop and ATRP polymerization, it synthesizes biodegradable amphiphilic triblock copolymer PEG-PCL-PDMAEMA. Composition and structure of the polymer is Characterized by 1H NMR and IR In this essay. This essay also studies that the polymer in water can be self-assembled to form a stable nanoparticles; The polymer micelle can form composite particles with siRNA,. This essay also studies the load and transfection of the polymer micelles on siRNA.