Details

Autor(en) / Beteiligte

• Rose, Adam J.
• Herzig, Stephan

Titel

Metabolic control through glucocorticoid hormones: An update

Ist Teil von

• Molecular and cellular endocrinology, 2013-11, Vol.380 (1-2), p.65-78

Ort / Verlag

Ireland: Elsevier Ireland Ltd

Erscheinungsjahr

2013

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• •The GC/GR axis represents a major checkpoint in systemic stress responses and metabolic control.•Tissue-specific actions of the GR control essential components of glucose, lipid, bile acid and protein homeostasis.•Novel roles of the GC/GR axis comprise the regulation of the molecular clock and brain-periphery communication. In the past decades, glucocorticoid (GC) hormones and their cognate, intracellular receptor, the glucocorticoid receptor (GR), have been well established as critical checkpoints in mammalian energy homeostasis. Whereas many aspects in healthy nutrient metabolism require physiological levels and/or action of GC, aberrant GC/GR signalling has been linked to severe metabolic dysfunction, including obesity, insulin resistance and type 2 diabetes. Consequently, studies of the molecular mechanisms within the GC signalling axis have become a major focus in biomedical research, up-to-date particularly focusing on systemic glucose and lipid handling. However, with the availability of novel high throughput technologies and more sophisticated metabolic phenotyping capabilities, as-yet non-appreciated, metabolic functions of GC have been recently discovered, including regulatory roles of the GC/GR axis in protein and bile acid homeostasis as well as metabolic inter-organ communication. Therefore, this review summarises recent advances in GC/GR biology, and summarises findings relevant for basic and translational metabolic research.