Details

Autor(en) / Beteiligte

• Cheng, Ching-Yuan
• Lee, Kwo-Whei
• Lee, Chiang-Hsuan
• Tyan, Yeu-Sheng
• Cheng, Cheng-Yi
• Wang, Jhi-Joung
• Yang, Chao-Wei
• Huang, Wen-Sheng
• Oliver Wong, Ching-Yee
• Yang, David J.

Titel

Time Sensitivity Factor of Single Pulmonary Nodule: A New Cancer Characteristic Metabolic Parameter by F 18 -FDG PET

Ist Teil von

• BioMed research international, 2014-01, Vol.2014, p.1-7

Ort / Verlag

New York: Hindawi Publishing Corporation

Erscheinungsjahr

2014

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Objective. To calculate the time sensitivity factor ( S ) for discriminating the solitary pulmonary nodule (SPN) by FDG PET at different time points. Methods. The multiple time-point FDG PET images from 41 patients for evaluating SPN seen on chest X-ray or CT were prospectively analyzed to calculate and evaluate S against the gold standard of tissue histology ( n = 38 ) or long term clinicoradiographic follow-up ( n = 3 ). The maximal standardized uptake values (SUV) at the 3 hourly time points were measured. The S was calculated using S = d { ln ⁡ ( SUV ) } / d { ln ⁡ ( t ) } at 3 different time intervals. ROC analysis of the S parameters was performed to evaluate the optimal cut-off value and their accuracy in classifying the SPN. Results. The SUV in malignant SPN was higher than the corresponding value in benign lesions at all 3 hourly time points ( P < 0.003 ). The S parameters using 3 different time intervals all significantly separated the two groups ( P < 0.0005 ) with an optimal cut-off point near the theoretical value of zero with a high sensitivity of 100% and specificity of 86%. Conclusion. The S can be calculated for SPNs using multiple time-point FDG PET, providing a tumor characteristic metabolic parameter with high discrimination power using a simple positive value representing malignancy.