Microbes and infection, 2013-06, Vol.15 (6-7), p.506-510
2013
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Details
- Autor(en) / Beteiligte
- Titel
- Chemically modified bovine beta-lactoglobulin inhibits human papillomavirus infection
- Ist Teil von
- Microbes and infection, 2013-06, Vol.15 (6-7), p.506-510
- Ort / Verlag
- France: Elsevier Masson SAS
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Previous studies have shown that 3-hydroxyphthalic anhydride-modified bovine beta-lactoglobulin is a promising anti-HIV microbicide candidate. Here we found that this chemically modified protein, designated JB01, exhibited highly potent antiviral activity against infection by human papillomaviruses (HPV), including HPV6, HPV16 and HPV18. Its anti-HPV activity was correlated with the percentage of modified lysine and arginine residues in JB01. This modified milk protein had no cytotoxicity at the concentration of 1 mg/ml, and it is highly stable at room temperature and 37 °C for at least 12 weeks. These results suggest that JB01 has good potential to be developed as an effective, safe and inexpensive antiviral agent for treatment and prevention of HPV infection.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1286-4579eISSN: 1769-714XDOI: 10.1016/j.micinf.2013.03.003Titel-ID: cdi_proquest_miscellaneous_1566852398
- Format
- –
- Schlagworte
- 3-Hydroxyphthalic anhydride, Animals, Anti-HPV agent, Antiviral Agents - chemistry, Antiviral Agents - pharmacology, Antiviral Agents - toxicity, Bovine beta-lactoglobulin, Cattle, Cell Line, Cell Survival - drug effects, Cervical cancer, Chemical modification, HPV infection, Human immunodeficiency virus, Human papillomavirus, Human papillomavirus 16, Human papillomavirus 16 - drug effects, Human papillomavirus 16 - growth & development, Human papillomavirus 18, Human papillomavirus 18 - drug effects, Human papillomavirus 18 - growth & development, Human papillomavirus 6 - drug effects, Human papillomavirus 6 - growth & development, Humans, Inhibitory Concentration 50, Lactoglobulins - chemistry, Lactoglobulins - pharmacology, Lactoglobulins - toxicity, Phthalic Anhydrides - chemistry, Phthalic Anhydrides - pharmacology, Phthalic Anhydrides - toxicity, Protein Stability, Structure-Activity Relationship, Temperature, Time Factors