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Staphylococcus aureus chronic and relapsing infections: Evidence of a role for persister cells
Ist Teil von
BioEssays, 2014-10, Vol.36 (10), p.991-996
Ort / Verlag
Cambridge: Blackwell Publishing Ltd
Erscheinungsjahr
2014
Link zum Volltext
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Staphylococcus aureus is an opportunistic pathogen capable of causing a variety of diseases including osteomyelitis, endocarditis, infections of indwelling devices and wound infections. These infections are often chronic and highly recalcitrant to antibiotic treatment. Persister cells appear to be central to this recalcitrance. A multitude of factors contribute to S. aureus virulence and high levels of treatment failure. These include its ability to colonize the skin and nares of the host, its ability to evade the host immune system and its development of resistance to a variety of antibiotics. Less understood is the phenomenon of persister cells and their role in S. aureus infections and treatment outcome. Persister cells occur as a sub‐population of phenotypic variants that are tolerant to antibiotic treatment. This review examines the importance of persisters in chronic and relapsing S. aureus infections and proposes methods for their eradication.
Staphylococcus aureus causes a range of biofilm related chronic and relapsing infections. The recalcitrance of these infections to antibiotic treatment can be explained by the presence of persister cells, phenotypic variants that tolerate high levels of antibiotic. Targeting these persisters will facilitate improved treatment of these infections.