Details

Autor(en) / Beteiligte

• Krul, Sébastien P.J., MD
• Meijborg, Veronique M.F., MSc
• Berger, Wouter R., MD
• Linnenbank, André C., PhD
• Driessen, Antoine H.G., MD
• van Boven, Wim-Jan, MD, PhD
• Wilde, Arthur A.M., MD, PhD
• de Bakker, Jacques M., PhD
• Coronel, Ruben, MD, PhD
• de Groot, Joris R., MD, PhD

Titel

Disparate response of high-frequency ganglionic plexus stimulation on sinus node function and atrial propagation in patients with atrial fibrillation

Ist Teil von

• Heart rhythm, 2014-10, Vol.11 (10), p.1743-1751

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2014

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Background In patients with atrial fibrillation (AF), the autonomic nervous system is supposed to play an role in triggering AF; however, little is known of the effect on atrial conduction characteristics. Objective The purpose of this study was to study the effect of ganglionic plexus (GP) stimulation during sinus rhythm on atrial and pulmonary vein conduction in patients during thoracoscopic surgery for AF Methods In 25 patients, the anterior right ganglionic plexus (ARGP) was stimulated (16 Hz, at 1, 2, and 5 mA). Epicardial electrograms were recorded using a 48-electrode map from the right pulmonary vein (RPV) or right atrial (RA). Intra-atrial activation time (IAT), local activation time (LAT), and inhomogeneity of conduction (IIC) were determined. ECG parameters (P-P, P-R interval) were measured. Results P-P interval was 956 ± 157 ms (range 768–1368 ms), and P-R interval was 203 ± 37 ms (range 136–280 ms). After ARGP stimulation, a short-lasting increase of P-P interval was observed, more prominent at higher output (1 mA = 82 ms, 2 mA = 180 ms, 5 mA = 268 ms, all P <.01 vs baseline). P-R interval remained unchanged. IAT was 34.4 ms (range 5.6–50.3 ms) at the RA and 105.8 ms (range 79.7–163.3 ms) at the RPV. After 1-mA stimulation IAT increased, in patients taking beta-blockers ( P = .001), or it decreased, and this change persisted after subsequent stimulation at higher current (1 mA, P = .001; 2 mA, P = .401; 5 mA, P = .593). Similar changes were observed for LAT and IIC. Conclusion ARGP stimulation results in a short-lasting, output-dependent decrease in sinus node frequency due to a parasympathetic response. Stimulation of the ARGP induced a prolonged increase or decrease in conduction characteristics in patients with AF, consistent with a persistent differential parasympathetic and/or sympathetic response.