Details

Autor(en) / Beteiligte

• Peng, Haihui
• Xi, Yumeng
• Ronaghi, Nima
• Dong, Boliang
• Akhmedov, Novruz G
• Shi, Xiaodong

Titel

Gold-Catalyzed Oxidative Cross-Coupling of Terminal Alkynes: Selective Synthesis of Unsymmetrical 1,3-Diynes

Ist Teil von

• Journal of the American Chemical Society, 2014-09, Vol.136 (38), p.13174-13177

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Gold-catalyzed oxidative cross-coupling of alkynes to unsymmetrical diynes has been achieved for the first time. A N,N-ligand (1,10-Phen) and PhI­(OAc)2 were identified as crucial factors to promote this transformation, giving the desired cross-coupled conjugated diynes in excellent hetero­selectivity (>10:1), in good to excellent yields, and with large substrate tolerability.