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Details

Autor(en) / Beteiligte
Titel
Antioxidants and human diseases
Ist Teil von
  • Clinica chimica acta, 2014-09, Vol.436, p.332-347
Ort / Verlag
Netherlands: Elsevier B.V
Erscheinungsjahr
2014
Link zum Volltext
Quelle
Elsevier ScienceDirect Journals Complete
Beschreibungen/Notizen
  • Oxidative stress plays a pivotal role in the development of human diseases. Reactive oxygen species (ROS) that includes hydrogen peroxide, hyphochlorus acid, superoxide anion, singlet oxygen, lipid peroxides, hypochlorite and hydroxyl radical are involved in growth, differentiation, progression and death of the cell. They can react with membrane lipids, nucleic acids, proteins, enzymes and other small molecules. Low concentrations of ROS has an indispensable role in intracellular signalling and defence against pathogens, while, higher amounts of ROS play a role in number of human diseases, including arthritis, cancer, diabetes, atherosclerosis, ischemia, failures in immunity and endocrine functions. Antioxidants presumably act as safeguard against the accumulation of ROS and their elimination from the system. The aim of this review is to highlight advances in understanding of the ROS and also to summarize the detailed impact and involvement of antioxidants in selected human diseases. •Oxidative stress plays a pivotal role in the development of human diseases.•Low concentrations of ROS have an indispensable role in intracellular signaling and defense against pathogens.•Higher amounts of ROS play a role in number of human diseases.•Antioxidants plays safeguard against the accumulation of ROS and their elimination from the system.
Sprache
Englisch
Identifikatoren
ISSN: 0009-8981, 1873-3492
eISSN: 1873-3492
DOI: 10.1016/j.cca.2014.06.004
Titel-ID: cdi_proquest_miscellaneous_1564606905

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