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TLR7 promotes tumor progression, chemotherapy resistance, and poor clinical outcomes in non-small cell lung cancer
Cancer research (Chicago, Ill.), 2014-09, Vol.74 (18), p.5008-5018
Chatterjee, Saradiya
Crozet, Lucile
Damotte, Diane
Iribarren, Kristina
Schramm, Catherine
Alifano, Marco
Lupo, Audrey
Cherfils-Vicini, Julien
Goc, Jeremy
Katsahian, Sandrine
Younes, Mohammad
Dieu-Nosjean, Marie Caroline
Fridman, Wolf Herman
Sautès-Fridman, Catherine
Cremer, Isabelle
2014
Details
Autor(en) / Beteiligte
Chatterjee, Saradiya
Crozet, Lucile
Damotte, Diane
Iribarren, Kristina
Schramm, Catherine
Alifano, Marco
Lupo, Audrey
Cherfils-Vicini, Julien
Goc, Jeremy
Katsahian, Sandrine
Younes, Mohammad
Dieu-Nosjean, Marie Caroline
Fridman, Wolf Herman
Sautès-Fridman, Catherine
Cremer, Isabelle
Titel
TLR7 promotes tumor progression, chemotherapy resistance, and poor clinical outcomes in non-small cell lung cancer
Ist Teil von
Cancer research (Chicago, Ill.), 2014-09, Vol.74 (18), p.5008-5018
Ort / Verlag
United States
Erscheinungsjahr
2014
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Toll-like receptors (TLR) recognize pathogen molecules and danger-associated signals that stimulate inflammatory processes. TLRs have been studied mainly in antigen-presenting cells, where they exert important immune regulatory functions, but they are also expressed by epithelial tumor cells, where they have been implicated in tumor progression. In this study, we demonstrate that the injection of TLR7 agonist in NOD/SCID mice, in C57BL/6 wild-type, and TLR7-deficient mice grafted with lung adenocarcinoma tumor cells leads to increased tumor progression and chemotherapeutic resistance. In patients with non-small cell lung cancer, expression analyses revealed that high TLR7 expression was strongly associated with resistance to neoadjuvant chemotherapy and poor clinical outcomes. Our findings delineate a crucial role for TLR7 in lung cancer physiopathology. Cancer Res; 74(18); 5008-18. ©2014 AACR.
Sprache
Englisch
Identifikatoren
ISSN: 0008-5472
eISSN: 1538-7445
DOI: 10.1158/0008-5472.can-13-2698
Titel-ID: cdi_proquest_miscellaneous_1562661795
Format
–
Schlagworte
Animals
,
Carcinoma, Non-Small-Cell Lung - drug therapy
,
Carcinoma, Non-Small-Cell Lung - metabolism
,
Cell Line, Tumor
,
Disease Progression
,
Female
,
Guanosine - analogs & derivatives
,
Guanosine - pharmacology
,
Humans
,
Lung Neoplasms - drug therapy
,
Lung Neoplasms - metabolism
,
Membrane Glycoproteins - agonists
,
Membrane Glycoproteins - metabolism
,
Mice
,
Mice, Inbred C57BL
,
Mice, Inbred NOD
,
Mice, SCID
,
Signal Transduction
,
Toll-Like Receptor 7 - agonists
,
Toll-Like Receptor 7 - metabolism
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