Details

Autor(en) / Beteiligte

• Erlinger, Serge

Titel

Bile acids in cholestasis: Bad for the liver, not so good for the kidney

Ist Teil von

• Clinics and research in hepatology and gastroenterology, 2014-09, Vol.38 (4), p.392-394

Ort / Verlag

France

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Summary The elegant paper by Fickert et al. on bile duct ligated mice provides convincing evidence for the hypothesis that bile acids retained in the serum during cholestasis and excreted through the kidneys are toxic to collecting duct cells. The authors propose that bile acids initiate a chain of reactions leading to tubulointerstitial nephritis and fibrosis. Mice with cholestasis were protected by prefeeding with the hydrophilic bile acid nor ursodeoxycholic acid, an observation which suggests a potential therapeutic option for cholemic nephropathy.