Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (35), p.12913-12918
2014
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Details
- Autor(en) / Beteiligte
- Titel
- Optogenetic neuronal stimulation promotes functional recovery after stroke
- Ist Teil von
- Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (35), p.12913-12918
- Ort / Verlag
- United States: National Academy of Sciences
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Significance Stroke is the leading cause of disability in the United States and has very limited treatment options. Brain stimulation techniques that promote recovery after stroke are a promising area of research; however, current stimulation techniques nonspecifically activate/inhibit the target area, which not only leads to undesired side effects but also makes it difficult to understand which cell types and mechanisms drive recovery. We used the optogenetic technique to specifically stimulate only neurons after stroke and demonstrate that selective neuronal stimulations can activate beneficial mechanisms and promote recovery. Understanding the cell type and mechanisms driving recovery may identify potential drug targets for stroke treatment, as well as ultimately help develop precise brain stimulation techniques for stroke therapy.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0027-8424eISSN: 1091-6490DOI: 10.1073/pnas.1404109111Titel-ID: cdi_proquest_miscellaneous_1561033703
- Format
- –
- Schlagworte
- Animals, Bacterial Proteins - genetics, Behavior, Animal - physiology, Behavioral neuroscience, Biological Sciences, Blood flow, Cerebral hemispheres, Cerebrovascular Circulation - physiology, Cerebrovascular Circulation - radiation effects, Channelrhodopsins, Corpus Striatum - physiology, Corpus Striatum - radiation effects, Disease Models, Animal, Electrodes, GAP-43 Protein - genetics, Genetics, Halorhodopsins - physiology, Infarction, Middle Cerebral Artery - physiopathology, Infarction, Middle Cerebral Artery - therapy, Laser Therapy - methods, Lasers, Light, Luminescent Proteins - genetics, Male, Mental stimulation, Mice, Mice, Transgenic, Motor cortex, Motor Cortex - physiopathology, Motor Cortex - radiation effects, Nerve Growth Factor - genetics, Neuronal Plasticity - physiology, Neuronal Plasticity - radiation effects, Neurons, Optical Fibers, Photic Stimulation - methods, Recovery of Function - physiology, Recovery of Function - radiation effects, Renovations, Rodents, Somatosensory Cortex - physiology, Somatosensory Cortex - radiation effects, Stroke, Strokes