Details

Autor(en) / Beteiligte

• Madhi, Shabir A
• Cutland, Clare L
• Kuwanda, Locadiah
• Weinberg, Adriana
• Hugo, Andrea
• Jones, Stephanie
• Adrian, Peter V
• van Niekerk, Nadia
• Treurnicht, Florette
• Ortiz, Justin R
• Venter, Marietjie
• Violari, Avy
• Neuzil, Kathleen M
• Simões, Eric A.F
• Klugman, Keith P
• Nunes, Marta C

Titel

Influenza Vaccination of Pregnant Women and Protection of Their Infants

Ist Teil von

• The New England journal of medicine, 2014-09, Vol.371 (10), p.918-931

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• In two trials of a trivalent inactivated influenza vaccine in pregnant women in South Africa, HIV-infected and HIV-uninfected vaccine recipients had increased influenza antibody titers and decreased influenza attack rates. Pregnant women are designated as a priority group for seasonal influenza vaccination by the World Health Organization (WHO) 1 because of their heightened susceptibility to severe influenza from the second trimester to the early postpartum period. 2 , 3 Since pregnancy is associated with immunomodulation, including the attenuation of cell-mediated immune responses, 4 the efficacy of inactivated influenza vaccine (IIV) in pregnant women may differ from its efficacy in healthy nonpregnant women and in men. 5 This difference in vaccine efficacy could be further accentuated in pregnant women infected with the human immunodeficiency virus (HIV), who are at heightened risk for severe influenza illness 6 – . . .