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Influenza Vaccination of Pregnant Women and Protection of Their Infants
Ist Teil von
The New England journal of medicine, 2014-09, Vol.371 (10), p.918-931
Ort / Verlag
Waltham, MA: Massachusetts Medical Society
Erscheinungsjahr
2014
Quelle
MEDLINE
Beschreibungen/Notizen
In two trials of a trivalent inactivated influenza vaccine in pregnant women in South Africa, HIV-infected and HIV-uninfected vaccine recipients had increased influenza antibody titers and decreased influenza attack rates.
Pregnant women are designated as a priority group for seasonal influenza vaccination by the World Health Organization (WHO)
1
because of their heightened susceptibility to severe influenza from the second trimester to the early postpartum period.
2
,
3
Since pregnancy is associated with immunomodulation, including the attenuation of cell-mediated immune responses,
4
the efficacy of inactivated influenza vaccine (IIV) in pregnant women may differ from its efficacy in healthy nonpregnant women and in men.
5
This difference in vaccine efficacy could be further accentuated in pregnant women infected with the human immunodeficiency virus (HIV), who are at heightened risk for severe influenza illness
6
– . . .