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Laminin regulates the osteogenic differentiation of dental follicle cells via integrin- alpha 2/- beta 1 and the activation of the FAK/ERK signaling pathway
Ist Teil von
Cell and tissue research, 2014-07, Vol.357 (1), p.345-354
Erscheinungsjahr
2014
Link zum Volltext
Quelle
SpringerLink Journals - AutoHoldings
Beschreibungen/Notizen
Dental follicle cells (DFCs) are ideal for studies concerning the differentiation of dental precursor cells into alveolar osteoblasts and cementoblasts. Previous investigations have suggested that the extracellular matrix (ECM) protein laminin and the ECM receptor integrin- alpha 2/- beta 1 play regulatory roles during the osteogenic differentiation of DFCs. Our present data indicate that laminin impairs alkaline phosphatase (ALP) activity following osteogenic induction while inducing integrin- alpha 2/- beta 1 expression, osteogenic differentiation marker elevation, and DFC biomineralization. Integrin- alpha 2/- beta 1 facilitates the laminin-dependent expression of osteogenic differentiation markers and the laminin-dependent inhibition of ALP activity. Moreover, these laminin-dependent effects on the osteogenic differentiation of DFCs can be reversed by the inhibition of the FAK/ERK signaling pathway. Thus, laminin regulates the inhibition of early osteogenic differentiation markers and the induction of late osteogenic differentiation markers via integrin- alpha 2/- beta 1 and the activation of the FAK/ERK signaling pathway.
Sprache
Englisch
Identifikatoren
ISSN: 0302-766X
eISSN: 1432-0878
DOI: 10.1007/s00441-014-1869-x
Titel-ID: cdi_proquest_miscellaneous_1560128866
Format
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