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Neuronal and glial differentiation during lizard (Gallotia galloti) visual system ontogeny
Journal of comparative neurology (1911), 2012-07, Vol.520 (10), p.2163-2184
Romero-Alemán, M.M.
Monzón-Mayor, M.
Santos, E.
Lang, D.M.
Yanes, C.
2012
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Romero-Alemán, M.M.
Monzón-Mayor, M.
Santos, E.
Lang, D.M.
Yanes, C.
Titel
Neuronal and glial differentiation during lizard (Gallotia galloti) visual system ontogeny
Ist Teil von
Journal of comparative neurology (1911), 2012-07, Vol.520 (10), p.2163-2184
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2012
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
We studied the histogenesis of the lizard visual system (E30 to adulthood) by using a selection of immunohistochemical markers that had proved relevant for other vertebrates. By E30, the Pax6+ pseudostratified retinal epithelium shows few newborn retinal ganglion cells (RGCs) in the centrodorsal region expressing neuron‐ and synaptic‐specific markers such as betaIII‐tubulin (Tuj1), synaptic vesicle protein‐2 (SV2), and vesicular glutamate transporter‐1 (VGLUT1). Concurrently, pioneer RGC axons run among the Pax2+ astroglia in the optic nerve and reach the superficial optic tectum. Between E30 and E35, the optic chiasm and optic tract remain acellular, but the latter contains radial processes with subpial endfeet expressing vimentin (Vim). From E35, neuron‐ and synaptic‐specific stainings spread in the retina and optic tectum, whereas retinal Pax6, and Tuj1/SV2 in RGC axons decrease. Müller glia and abundant optic nerve glia express a variety of glia‐specific markers until adulthood. Subpopulations of optic nerve glia are also VGLUT1+ and cluster differentiation‐44 (CD44)‐positive but cytokeratin‐negative, unlike the case in other regeneration‐competent species. Specifically, coexpression of CD44/Vim and glutamine synthetase (GS)/VGLUT1 reflects glial specialization, insofar as most CD44+ glia are GS−. In the adult optic tract and tectum, radial glia and free astroglia coexist. The latter show different immunocharacterization (Pax2−/CD44−/Vim−) compared with that in the optic nerve. We conclude that upregulation of Tuj1 and SV2 is required for axonal outgrowth and search for appropriate targets, whereas Pax2+ optic nerve astroglia and Vim+ radial glia may aid in early axonal guidance. Spontaneous axonal regrowth seems to succeed despite the heterogeneous mammalian‐like glial environment in the lizard optic nerve. J. Comp. Neurol. 520:2163–2184, 2012. © 2011 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0021-9967
eISSN: 1096-9861
DOI: 10.1002/cne.23034
Titel-ID: cdi_proquest_miscellaneous_1560123531
Format
–
Schlagworte
Animals
,
Animals, Newborn
,
axonal growth
,
Cell Differentiation - physiology
,
Gallotia galloti
,
Gene Expression Regulation, Developmental - physiology
,
gliogenesis
,
Hyaluronan Receptors - metabolism
,
Lacertilia
,
Lizards - anatomy & histology
,
Lizards - embryology
,
Lizards - growth & development
,
Nerve Tissue Proteins - metabolism
,
neurogenesis
,
Neuroglia - physiology
,
Neurons - physiology
,
PAX2 Transcription Factor - metabolism
,
reptile
,
retinotectal system
,
Synapses - metabolism
,
synaptogenesis
,
Tubulin - metabolism
,
Visual Pathways - cytology
,
Visual Pathways - embryology
,
Visual Pathways - growth & development
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