Details

Autor(en) / Beteiligte

• Shi, Xian-Ying
• Renzetti, Andrea
• Kundu, Soumen
• Li, Chao-Jun

Titel

A Rhodium-Catalyzed Cascade Cyclization: Direct Synthesis of N-Substituted Phthalimides from Isocyanates and Benzoic Acids

Ist Teil von

• Advanced synthesis & catalysis, 2014-03, Vol.356 (4), p.723-728

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• A rhodium(III)‐catalyzed amidation between benzoic acids and isocyanates via direct functionalization of an ortho CH bond followed by intramolecular cyclization is described. This cascade cyclization affords N‐substituted phthalimides in one step in 26–91% yields. The reaction is highly atom‐economical, since no theoretical waste except for water is generated in the reaction.