Details

Autor(en) / Beteiligte

• Yuan, DeJian
• Zhu, ZuoBin
• Tan, XiaoHua
• Liang, Jie
• Zeng, Chen
• Zhang, JieGen
• Chen, Jun
• Ma, Long
• Dogan, Ayca
• Brockmann, Gudrun
• Goldmann, Oliver
• Medina, Eva
• Rice, Amanda D.
• Moyer, Richard W.
• Man, Xian
• Yi, Ke
• Li, YanKe
• Lu, Qing
• Huang, YiMin
• Huang, Shi

Titel

Scoring the collective effects of SNPs： association of minor alleles with complex traits in model organisms

Ist Teil von

• Science China. Life sciences, 2014-09, Vol.57 (9), p.876-888

Ort / Verlag

Beijing: Science China Press

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• It has long been assumed that most parts of a genome and most genetic variations or SNPs are non-functional with regard to reproductive fitness. However, the collective effects of SNPs have yet to be examined by experimental science. We here de- veloped a novel approach to examine the relationship between traits and the total amount of SNPs in panels of genetic refer- ence populations. We identified the minor alleles （MAs） in each panel and the MA content （MAC） that each inbred strain car- ried for a set of SNPs with genotypes determined in these panels. MAC was nearly linearly linked to quantitative variations in numerous traits in model organisms, including life span, tumor susceptibility, learning and memory, sensitivity to alcohol and anti-psychotic drugs, and two correlated traits poor reproductive fitness and strong immunity. These results suggest that the collective effects of SNPs are functional and do affect reproductive fitness.