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Mechanism for sodium bicarbonate inhibition of trichothecene biosynthesis in Fusarium tricinctum
Ist Teil von
Journal of agricultural and food chemistry, 1994-09, Vol.42 (9), p.2025-2028
Ort / Verlag
Washington, DC: American Chemical Society
Erscheinungsjahr
1994
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Treatment of Fusarium tricinctum NRRL 13426 cultures with dilute sodium bicarbonate resulted in dramatic reductions in the production of trichothecene mycotoxins, geraniol, and carotenoids. All of these compounds are biosynthesized from mevalonic acid (I). In addition, three apparent mevalonic acid metabolites were found in the bicarbonate-treated cultures at concentrations of several parts per million each. Two of these compounds were tentatively identified as 3-methyl-4-oxo-2-pentenoic acid (IV) and its rearrangement product, 4,5-dimethyl-5-hydroy-2(5H) furanone (VI). These results suggest a pH-related inhibition of mevalonate kinase or a pH-related activation of an enzyme that is responsible, at least in part, for the conversion of mevalonic acid to the pentenoic acid or its precursor