Details

Autor(en) / Beteiligte

• Racila, Emilian
• Hsueh, Robert
• Marches, Radu
• Tucker, Thomas F.
• Krammer, Peter H.
• Scheuermann, Richard H.
• Uhr, Jonathan W.

Titel

Tumor Dormancy and Cell Signaling: Anti-μ -Induced Apoptosis in Human B-Lymphoma Cells is not Caused by an APO-1-APO-1 Ligand Interaction

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 1996-03, Vol.93 (5), p.2165-2168

Ort / Verlag

United States: National Academy of Sciences of the United States of America

Erscheinungsjahr

1996

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Signal transduction initiated by crosslinking of antigen-specific receptors on T- and B-lymphoma cells induces apoptosis. In T-lymphoma cells, such crosslinking results in upregulation of the APO-1 ligand, which then interacts with induced or constitutively expressed APO-1, thereby triggering apoptosis. Here we show that crosslinking the membrane immunoglobulin on human lymphoma cells (Daudi) (that constitutively express APO-1) does not induce synthesis of APO-1 ligand. Further, a noncytotoxic fragment of anti-APO-1 antibody that blocks T-cell-receptor-mediated apoptosis in T-lymphoma cells does not block anti-μ -induced apoptosis. Hence, in B-lymphoma cells, apoptosis induced by signaling via membrane IgM is not mediated by the APO-1 ligand.