Details

Autor(en) / Beteiligte

• Zhang, Xiang-Yu
• Yang, Bing-Ya
• Wang, Jia-Yu
• Mo, Xuan
• Zhang, Jing
• Hua, Zi-Chun

Titel

FADD is essential for glucose uptake and survival of thymocytes

Ist Teil von

• Biochemical and biophysical research communications, 2014-08, Vol.451 (2), p.202-207

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• •FADD deficiency leads to increased apoptosis and a reduction of thymocytes numbers.•Glucose uptake and Glut1 expression is repressed in FADD−/− thymocytes.•FADD deficiency results in abnormal Akt phosphorylation and activation in thymocytes.•The accumulation of PKC-α may repress Akt signal transduction in FADD−/− thymocytes. Fas-associated protein with death domain (FADD) has been implicated in T lymphocytes, but the nature of FADD-dependent mechanism in early T cell development has not been completely elucidated. In this study, using T-cell specific deletion mice, we observed that FADD deficiency in thymocytes led to increased apoptosis and reduced cell numbers, which may be attributed to the reduction of Glut1 expression and correspondingly decreased glucose uptake. Furthermore, an abnormal transduction of Akt signaling was discovered in FADD−/− thymocytes, which may be responsible for the declined Glut1 expression. Collectively, our results demonstrate the new function of FADD in glucose metabolism and survival of early T cells.