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BibTeX
Next Generation Drying Technologies for Pharmaceutical Applications
Journal of pharmaceutical sciences, 2014-09, Vol.103 (9), p.2673-2695
Walters, Robert H.
Bhatnagar, Bakul
Tchessalov, Serguei
Izutsu, Ken-Ichi
Tsumoto, Kouhei
Ohtake, Satoshi
2014
Details
Autor(en) / Beteiligte
Walters, Robert H.
Bhatnagar, Bakul
Tchessalov, Serguei
Izutsu, Ken-Ichi
Tsumoto, Kouhei
Ohtake, Satoshi
Titel
Next Generation Drying Technologies for Pharmaceutical Applications
Ist Teil von
Journal of pharmaceutical sciences, 2014-09, Vol.103 (9), p.2673-2695
Ort / Verlag
United States: Elsevier Inc
Erscheinungsjahr
2014
Link zum Volltext
Quelle
Wiley Blackwell Single Titles
Beschreibungen/Notizen
Drying is a commonly used technique for improving the product stability of biotherapeutics. Typically, drying is accomplished through freeze-drying, as evidenced by the availability of several lyophilized products on the market. There are, however, a number of drawbacks to lyophilization, including the lengthy process time required for drying, low energy efficiency, high cost of purchasing and maintaining the equipment, and sensitivity of the product to freezing and various other processing-related stresses. These limitations have led to the search for next-generation drying methods that can be applied to biotherapeutics. Several alternative drying methods are reviewed herein, with particular emphasis on methods that are commonly employed outside of the biopharmaceutical industry including spray drying, convective drying, vacuum drying, microwave drying, and combinations thereof. Although some of the technologies have already been implemented for processing biotherapeutics, others are still at an early stage of feasibility assessment. An overview of each method is presented, detailing the comparison to lyophilization, examining the advantages and disadvantages of each technology, and evaluating the potential of each to be utilized for drying biotherapeutic products. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:2673–2695, 2014
Sprache
Englisch
Identifikatoren
ISSN: 0022-3549
eISSN: 1520-6017
DOI: 10.1002/jps.23998
Titel-ID: cdi_proquest_miscellaneous_1555249074
Format
–
Schlagworte
Chemistry, Pharmaceutical - methods
,
dehydration
,
drying
,
foam drying
,
Freeze Drying - methods
,
freeze-drying
,
hybrid drying
,
microwave
,
Pharmaceutical Preparations - chemistry
,
processing
,
proteins
,
spray drying
,
supercritical fluids
,
Technology, Pharmaceutical - methods
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