Nature neuroscience, 2013-09, Vol.16 (9), p.1248-1256
2013
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- Autor(en) / Beteiligte
- Titel
- Toll-6 and Toll-7 function as neurotrophin receptors in the Drosophila melanogaster CNS
- Ist Teil von
- Nature neuroscience, 2013-09, Vol.16 (9), p.1248-1256
- Ort / Verlag
- United States: Nature Publishing Group
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Neurotrophin receptors corresponding to vertebrate Trk, p75(NTR) or Sortilin have not been identified in Drosophila, thus it is unknown how neurotrophism may be implemented in insects. Two Drosophila neurotrophins, DNT1 and DNT2, have nervous system functions, but their receptors are unknown. The Toll receptor superfamily has ancient evolutionary origins and a universal function in innate immunity. Here we show that Toll paralogs unrelated to the mammalian neurotrophin receptors function as neurotrophin receptors in fruit flies. Toll-6 and Toll-7 are expressed in the CNS throughout development and regulate locomotion, motor axon targeting and neuronal survival. DNT1 (also known as NT1 and spz2) and DNT2 (also known as NT2 and spz5) interact genetically with Toll-6 and Toll-7, and DNT1 and DNT2 bind to Toll-6 and Toll-7 promiscuously and are distributed in vivo in domains complementary to or overlapping with those of Toll-6 and Toll-7. We conclude that in fruit flies, Tolls are not only involved in development and immunity but also in neurotrophism, revealing an unforeseen relationship between the neurotrophin and Toll protein families.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1097-6256eISSN: 1546-1726DOI: 10.1038/nn.3474Titel-ID: cdi_proquest_miscellaneous_1554947147
- Format
- –
- Schlagworte
- Animals, Animals, Genetically Modified, Brain-derived neurotrophic factor, Cells, Cultured, Central Nervous System - embryology, Central Nervous System - growth & development, Central Nervous System - metabolism, Drosophila, Drosophila melanogaster, Drosophila Proteins - genetics, Drosophila Proteins - metabolism, Embryo, Nonmammalian, Evolution, Gene Expression Regulation, Developmental - genetics, Genomes, Green Fluorescent Proteins - genetics, Insects, Larva, Locomotion - genetics, Nerve Tissue Proteins - metabolism, Nervous system, Neurons, Neurons - metabolism, Neurotrophic functions, Physiological aspects, Protein Binding - genetics, Proteins, Receptors, Nerve Growth Factor - genetics, Receptors, Nerve Growth Factor - metabolism, RNA, Messenger - metabolism, Toll-Like Receptor 6 - genetics, Toll-Like Receptor 6 - metabolism, Toll-Like Receptor 7 - genetics, Toll-Like Receptor 7 - metabolism, Toll-like receptors, Transfection