Details

Autor(en) / Beteiligte

• He, Jing
• Tsai, Louis M.
• Leong, Yew Ann
• Hu, Xin
• Ma, Cindy S.
• Chevalier, Nina
• Sun, Xiaolin
• Vandenberg, Kirsten
• Rockman, Steve
• Ding, Yan
• Zhu, Lei
• Wei, Wei
• Wang, Changqi
• Karnowski, Alexander
• Belz, Gabrielle T.
• Ghali, Joanna R.
• Cook, Matthew C.
• Riminton, D. Sean
• Veillette, André
• Schwartzberg, Pamela L.
• Mackay, Fabienne
• Brink, Robert
• Tangye, Stuart G.
• Vinuesa, Carola G.
• Mackay, Charles R.
• Li, Zhanguo
• Yu, Di

Titel

Circulating Precursor CCR7loPD-1hi CXCR5+ CD4+ T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure

Ist Teil von

• Immunity (Cambridge, Mass.), 2013-10, Vol.39 (4), p.770-781

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2013

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Follicular B helper T (Tfh) cells support high affinity and long-term antibody responses. Here we found that within circulating CXCR5+ CD4+ T cells in humans and mice, the CCR7loPD-1hi subset has a partial Tfh effector phenotype, whereas CCR7hiPD-1lo cells have a resting phenotype. The circulating CCR7loPD-1hi subset was indicative of active Tfh differentiation in lymphoid organs and correlated with clinical indices in autoimmune diseases. Thus the CCR7loPD-1hi subset provides a biomarker to monitor protective antibody responses during infection or vaccination and pathogenic antibody responses in autoimmune diseases. Differentiation of both CCR7hiPD-1lo and CCR7loPD-1hi subsets required ICOS and BCL6, but not SAP, suggesting that circulating CXCR5+ helper T cells are primarily generated before germinal centers. Upon antigen reencounter, CCR7loPD-1hi CXCR5+ precursors rapidly differentiate into mature Tfh cells to promote antibody responses. Therefore, circulating CCR7loPD-1hi CXCR5+ CD4+ T cells are generated during active Tfh differentiation and represent a new mechanism of immunological early memory. [Display omitted] •Circulating CXCR5+ CD4+ T cells comprise CCR7loPD-1hi and CCR7hiPD-1lo subsets•Circulating CXCR5+ CD4+ T cells are primarily generated before participating in GC•Circulating CCR7loPD-1hi CXCR5+ CD4+ T cells correlate with Tfh cell activity•Circulating CCR7loPD-1hi CXCR5+ CD4+ T cells promote antibody responses