Bulletin of experimental biology and medicine, 2014-08, Vol.157 (4), p.506-509
2014
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Dual Effects of Indoleamine 2,3-Dioxygenase Inhibitors on the Therapeutic Effects of Cyclophosphamide and Cycloplatam on Ehrlich Ascites Tumor in Mice
- Ist Teil von
- Bulletin of experimental biology and medicine, 2014-08, Vol.157 (4), p.506-509
- Ort / Verlag
- Boston: Springer US
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Ethyl pyruvate, an inhibitor of indoleamine 2,3-dioxygenase, slightly suppressed the growth of transplantable Ehrlich tumor in mice and signifi cantly potentiated the therapeutic effect of cyclophosphamide. Another inhibitor amidoxime produced a similar effect. However, both ethyl pyruvate and amidoxime signifi cantly reduced the effect of cycloplatam therapy. The observed changes can be stipulated by different effects of cyclophosphamide and cycloplatam on the subpopulations of lymphoid cells taking part in the formation of antitumor immunity and resistance to tumors.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0007-4888eISSN: 1573-8221DOI: 10.1007/s10517-014-2602-1Titel-ID: cdi_proquest_miscellaneous_1554468756
- Format
- –
- Schlagworte
- Animals, Antimitotic agents, Antineoplastic agents, Antineoplastic Agents - pharmacology, Biomedical and Life Sciences, Biomedicine, Carcinoma, Ehrlich Tumor - drug therapy, Carcinoma, Ehrlich Tumor - enzymology, Carcinoma, Ehrlich Tumor - immunology, Carcinoma, Ehrlich Tumor - pathology, Cell Biology, Cyclophosphamide, Cyclophosphamide - pharmacology, Drug Interactions, Drug Therapy, Combination, Enzyme Inhibitors - pharmacology, Female, Health aspects, Immunity, Innate - drug effects, Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors, Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism, Internal Medicine, Laboratory Medicine, Male, Mice, Mice, Inbred ICR, Oncology, Organoplatinum Compounds - pharmacology, Oximes - pharmacology, Pathology, Pyruvates - pharmacology, Tumor Burden - drug effects, Tumors