Vaccine, 2014-09, Vol.32 (39), p.5027-5034
2014
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- Autor(en) / Beteiligte
- Titel
- Comparison of the safety and immunogenicity of an MF59® -adjuvanted with a non-adjuvanted seasonal influenza vaccine in elderly subjects
- Ist Teil von
- Vaccine, 2014-09, Vol.32 (39), p.5027-5034
- Ort / Verlag
- Kidlington: Elsevier Ltd
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Non-adjuvanted influenza vaccines elicit a poor response in the elderly. • Adjuvanted and non-adjuvanted vaccines were compared in 7082 elderly subjects. • Adjuvanted influenza vaccine elicited a significantly higher antibody response. • Adjuvant enhanced antibody responses in subjects with underlying medical conditions. • Adjuvanted vaccine had significantly higher response against heterologous A strains.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0264-410XeISSN: 1873-2518DOI: 10.1016/j.vaccine.2014.07.013Titel-ID: cdi_proquest_miscellaneous_1554459353
- Format
- –
- Schlagworte
- Adjuvant, Adjuvants, Immunologic - pharmacology, Age, Aged, Allergy and Immunology, Antibodies, Viral - blood, Antibody Formation, Antigens, Applied microbiology, Biological and medical sciences, Confidence intervals, Elderly, Female, Fundamental and applied biological sciences. Psychology, Hemagglutination Inhibition Tests, Humans, Immunization, Immunogenicity, Influenza, Influenza A Virus, H3N2 Subtype, Influenza vaccine, Influenza Vaccines - immunology, Influenza Vaccines - therapeutic use, Influenza, Human - prevention & control, Male, MF59, Microbiology, Non-inferiority, Polysorbates - pharmacology, Population, Ratios, Single-Blind Method, Squalene - pharmacology, Superiority, Vaccine Potency, Vaccines, Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)